Sulfuryl chloride → 6-Bromo-8-chloro-7-ethoxy-2,2-dimethyl-chroman-4-one

HRID 2180459Notes

Reaction equation

HRID 2180459 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[O:8][C:7]([CH3:16])([CH3:15])[CH2:6][C:5]2=[O:17].S(Cl)([Cl:21])(=O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:21])[C:11]=1[O:12][CH2:13][CH3:14])[O:8][C:7]([CH3:16])([CH3:15])[CH2:6][C:5]2=[O:17]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 224909226-Bromo-7-ethoxy-2,2-dimethyl-chroman-4-one2×

Product 1

HCID 224907976-Bromo-8-chloro-7-ethoxy-2,2-dimethyl-chroman-4-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following General Procedure B, 6-bromo-7-ethoxy-2,2-dimethyl-chroman-4-one (Compound 5, 2.8 g, 9.33 mmol) and sulfuryl chloride (1.51 g, 11.2 mmol) in dichloromethane were reacted to yield the title compound as a colorless oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c090f63c06524bc3aff13a7c6639b472
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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