Sulfuryl chloride → 6-Bromo-8-chloro-7-isopropoxy-2,2-dimethyl-chroman-4-one

HRID 2180460Notes

Reaction equation

HRID 2180460 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH:13]([CH3:15])[CH3:14])[O:8][C:7]([CH3:17])([CH3:16])[CH2:6][C:5]2=[O:18].S(Cl)([Cl:22])(=O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:22])[C:11]=1[O:12][CH:13]([CH3:14])[CH3:15])[O:8][C:7]([CH3:16])([CH3:17])[CH2:6][C:5]2=[O:18]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 224909096-Bromo-7-isopropoxy-2,2-dimethyl-chroman-4-one2×

Product 1

HCID 224907866-Bromo-8-chloro-7-isopropoxy-2,2-dimethyl-chroman-4-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following General Procedure B, 6-bromo-7-isopropoxy-2,2-dimethyl-chroman-4-one, (Compound 6, 2.2 g, 7.0 mmol) and sulfuryl chloride (0.84 mL, 10.5 mmol) in dichloromethane were reacted to yield the title compound as white trapezoidal plates after recrystallization from hexanes.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-70fe9f8c19564365a39bda179e28725f
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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