HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 6-Bromo-4-ethyl-7-methoxy-2,2-dimethyl-2H-chromene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 6-Bromo-7-methoxy-2,2-dimethyl-chroman-4-one | HCID 13452277 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Bromo-4-ethyl-7-methoxy-2,2-dimethyl-2H-chromene | HCID 22490863 | — |
Reaction Steps
Following General Procedure C, ethylmagnesium bromide (2.0 M in THF, 4.7 mL, 14.08 mmol) was added to a solution of 6-bromo-7-methoxy-2,2-dimethyl-chroman-4-one (Compound 4, 800 mg, 2.81 mmol) in THF. The crude alcohol was treated with p-toluenesulfonic acid to afford the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887896B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-7ee37f9dad74489d90df1bb2c7d683d3 |
| Source note | uspto-grants-2005_05 |