HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 6-Bromo-4-methyl-7-ethoxy-2,2-dimethyl-2H-chromene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 6-Bromo-7-ethoxy-2,2-dimethyl-chroman-4-one | HCID 22490922 | — |
| Reactant | HCID 178418332 | HCID 178418332 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Bromo-4-methyl-7-ethoxy-2,2-dimethyl-2H-chromene | HCID 22491090 | — |
Reaction Steps
Following General Procedure C, methylmagnesium chloride (3 M in THF, 1.38 mL, 4.14 mmol) was added to a solution of 6-bromo-7-ethoxy-2,2-dimethyl-chroman-4-one (Compound 5, 588 mg, 2.07 mmol) in THF. The crude alcohol was treated with p-toluenesulfonic acid to afford the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887896B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-44ae1f6f6e6f4575a9ba409cc6f97e5b |
| Source note | uspto-grants-2005_05 |