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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2180485Generated: October 30, 2026

Iodoethane → 1-(4-Isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone

https://huagongshe.com/reaction/2180485

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoethaneHCID 6340—
ReactantPotassium CarbonateHCID 11430—
Reactant7-Hydroxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl-ethanoneHCID 22490917—
SolventAcetoneHCID 180—
Product1-(4-Isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)ethanoneHCID 22491047—

Reaction Steps

As described in General Procedure A, a solution of 1-(7-hydroxy-4 isopropyl-2,2-dimethyl-2H-chromen-6-yl)-ethanone (Compound 62, 205 mg, 0.69 mmol) in acetone were added ethyl iodide (0.3 mL, 3.45 mmol) and potassium carbonate (476 mg, 3.45 mmol) to give rise to the title compound as a colorless oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexanes).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06887896B1
Source datasetuspto-grants-2005_05
ORD IDord-14b050941e6a48f2a88d3abc76f81f9e
Source noteuspto-grants-2005_05