HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl 2-fluoro-2-phosphonoacetate → ethyl (2E)-fluoro-3-(4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)but-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl 2-fluoro-2-phosphonoacetate | HCID 2734865 | — |
| Reactant | 1-(4-tert-Butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethanone | HCID 22490773 | — |
| Product | ethyl (2E)-fluoro-3-(4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)but-2-enoate | HCID 86597829 | — |
Reaction Steps
Following General Procedure K, triethyl-2-fluoro-2-phosphonoacetate (0.47 mL, 2.3 mmol) and 1-(4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethanone (Compound 55, 133 mg, 0.46 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 ethyl acetate/hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887896B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-7f222a92aeaf4525b25afcc2bfe3e29e |
| Source note | uspto-grants-2005_05 |