Triethyl 2-fluoro-2-phosphonoacetate → ethyl (2E)-3-(2,2-dimethyl-4-phenyl-7-propoxy-2H-chromen-6-yl)-2-fluoro-but-2-enoate

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Reaction Steps

Following General Procedure K, triethyl-2-fluoro-2-phosphonoacetate (0.41 mL, 1.61 mmol) and 1-(2,2 dimethyl-4-phenyl-7-propoxy-2H-chromen-6-yl)-ethanone (Compound 67, 180 mg, 0.54 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 ethyl acetate/hexane).

Provenance & Evidence