Triethyl 2-fluoro-2-phosphonoacetate → HCID 69731551, compound

HRID 2180497Notes

Reaction equation

HRID 2180497 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6](P(OCC)(OCC)=O)[F:7])=[O:5].[CH:16]([C:19]1[C:28]2[C:23](=[CH:24][C:25]([O:33][CH3:34])=[C:26]([C:29](=O)[CH2:30][CH3:31])[CH:27]=2)[O:22][C:21]([CH3:36])([CH3:35])[CH:20]=1)([CH3:18])[CH3:17]>>[F:7]/[C:6](=[C:29](/[C:26]1[CH:27]=[C:28]2[C:23](=[CH:24][C:25]=1[O:33][CH3:34])[O:22][C:21]([CH3:36])([CH3:35])[CH:20]=[C:19]2[CH:16]([CH3:17])[CH3:18])\[CH2:30][CH3:31])/[C:4]([O:3][CH2:2][CH3:1])=[O:5]

Participants

3

Reactant 2

HCID 2734865Triethyl 2-fluoro-2-phosphonoacetateHCID 22491037HCID 22491037, compound2×

Product 1

HCID 69731551HCID 69731551, compound

Procedure

Following General Procedure K, triethyl-2-fluoro-2-phosphonoacetate (605 mg, 2.50 mmol) and 1-(4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-propan-1-one (Compound 58, 148 mg, 0.50 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexanes).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f9c5f64fbb6449b58e5254258655b765
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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