Triethyl 2-fluoro-2-phosphonoacetate → HCID 69753952, compound

HRID 2180499Notes

Reaction equation

HRID 2180499 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6](P(OCC)(OCC)=O)[F:7])=[O:5].[CH2:16]([O:18][C:19]1[CH:28]=[C:27]2[C:22]([C:23]([CH3:31])=[CH:24][C:25]([CH3:30])([CH3:29])[O:26]2)=[CH:21][C:20]=1[C:32](=O)[CH2:33][CH3:34])[CH3:17]>>[CH2:16]([O:18][C:19]1[CH:28]=[C:27]2[C:22]([C:23]([CH3:31])=[CH:24][C:25]([CH3:30])([CH3:29])[O:26]2)=[CH:21][C:20]=1/[C:32](/[CH2:33][CH3:34])=[C:6](/[F:7])\[C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH3:17]

Participants

3

Reactant 2

HCID 2734865Triethyl 2-fluoro-2-phosphonoacetateHCID 22490946HCID 22490946, compound2×

Product 1

HCID 69753952HCID 69753952, compound

Procedure

Following General Procedure K, triethyl-2-fluoro-2-phosphonoacetate (993 mg, 4.11 mmol) and 1-(7-ethoxy-4-methyl-2,2-dimethyl-2H-chromen-6-yl)-propan-1-one (Compound 60, 225 mg, 0.82 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexanes).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4bd08ce504af494b8c28aae7f31cef99
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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