Hydrazine → 3-(1-Methylpiperazin-2-YL)propan-1-amine

HRID 21805Notes

Reaction equation

HRID 21805 reaction equation
[NH2:1]N.[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12]C1C=CC=C2C(NC(=O)C=12)=O>CO>[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12][NH2:1]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 537877233-(N-methylpiperazinyl)propylphthalimide

Product 1

HCID 450994643-(1-Methylpiperazin-2-YL)propan-1-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrazine (aqueous solution at 35% by wt.) (0.15 ml; 1.6 mmoles) was added to 3-(N-methylpiperazinyl)propylphthalimide (229 mg; 0.8 mmoles) in methanol (5 ml) and the resulting solution was refluxed. Reaction times and process as per Example 1.

Workup

  1. temperaturethe resulting solution was refluxed
  2. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-c6c1e1d9583c4a30b639ec091611be7a
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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