Diisobutylaluminumhydride → (2E)-3-(4-tert-Butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol

Participants

Reaction Steps

Following General Procedure L, ethyl (2E)-fluoro-3-(4-tert-butyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)but-2-enoate (Compound 70, 148 mg, 0.39 mmol) and diisobutylaluminum hydride (1 M in dichloromethane, 1.1 mL, 1.1 mmol) were reacted to give the title compound as yellow solid after purification by flash chromatography (silica gel, 1:9 to 1:4 ethyl acetate/hexane).

Provenance & Evidence