HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminumhydride → (2E)-3-(7-Ethoxy-4-ethyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | ethyl (2E)-3-(7-ethoxy-4-ethyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enoate | HCID 86597830 | — |
| Product | (2E)-3-(7-Ethoxy-4-ethyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-en-1-ol | HCID 22491000 | — |
Reaction Steps
Following General Procedure L, ethyl (2E)-3-(7-ethoxy-4-ethyl-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enoate (Compound 71, 348 mg, 0.96 mmol) and diisobutylaluminum hydride (1 M dichloromethane, 2.9 mL, 2.88 mmol) were reacted to give the title compound as yellow solid after purification by flash chromatography (silica gel, 1:9 to 1:4 ethyl acetate/hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887896B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-3cd2995d57ae4f5881dad8c5a82ce078 |
| Source note | uspto-grants-2005_05 |