Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 86759709, compound

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Reaction Steps

Following General Procedure O, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (159 mg, 0.60 mmol) and (2E)-2-fluoro-3-(4-isopropyl-2,2-dimethyl-7-propoxy-2H-chromen-6-yl)but-2-enal (Compound 99, 72 mg, 0.21 mmol) were reacted to give the title compound as a yellow oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexane).

Provenance & Evidence