HRID2180522

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCOC(=O)/C=C(\C)CP(=O)(OCC)OCC$

HCID6000084

未命名化合物

结构：CCOc1cc2c(cc1/C(C)=C(/F)C=O)C(c1ccccc1)=CC(C)(C)O2

HCID22490763

未命名化合物

2 次

PRODUCTS

生成物

结构：CCOC(=O)/C=C(C)/C=C/C(F)=C(/C)c1cc2c(cc1OCC)OC(C)(C)C=C2c1ccccc1

HCID86759711

未命名化合物

PROCEDURE

实验过程

Following General Procedure O, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (237 mg, 0.90 mmol) and (2E)-3-(7-ethoxy-2,2-dimethyl-4-phenyl-2H-chromen-6-yl)-2-fluoro-but-2-enal (Compound 101, 113 mg, 0.31 mmol) were reacted to give the title compound as a yellow oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexane).

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a906f3239abe4e49aa70722a6531a483
来源数据集: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06887896B1
来源说明: uspto-grants-2005_05

反应 SMILES

C(OP([CH2:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[CH2:18]([O:20][C:21]1[CH:30]=[C:29]2[C:24]([C:25]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:26][C:27]([CH3:32])([CH3:31])[O:28]2)=[CH:23][C:22]=1/[C:39](/[CH3:44])=[C:40](/[F:43])\[CH:41]=O)[CH3:19]>>[CH2:18]([O:20][C:21]1[CH:30]=[C:29]2[C:24]([C:25]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:26][C:27]([CH3:32])([CH3:31])[O:28]2)=[CH:23][C:22]=1/[C:39](/[CH3:44])=[C:40](/[F:43])\[CH:41]=[CH:9]\[C:10](\[CH3:17])=[CH:11]\[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:19]