Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 86759712, compound

HRID 2180523Notes

Reaction equation

HRID 2180523 reaction equation
C(OP([CH2:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[CH3:18][C:19]1([CH3:45])[CH:28]=[C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:26]2[C:21](=[CH:22][C:23]([O:41][CH2:42][CH2:43][CH3:44])=[C:24](/[C:35](/[CH3:40])=[C:36](/[F:39])\[CH:37]=O)[CH:25]=2)[O:20]1>>[CH3:18][C:19]1([CH3:45])[CH:28]=[C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:26]2[C:21](=[CH:22][C:23]([O:41][CH2:42][CH2:43][CH3:44])=[C:24](/[C:35](/[CH3:40])=[C:36](/[F:39])\[CH:37]=[CH:9]\[C:10](\[CH3:17])=[CH:11]\[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:25]=2)[O:20]1

Participants

3

Reactant 2

HCID 6000084Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoateHCID 22490770HCID 22490770, compound2×

Product 1

HCID 86759712HCID 86759712, compound

Procedure

Following General Procedure O, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (237 mg, 0.83 mmol) and (2E)-3-(2,2-dimethyl-4-phenyl-7-propoxy-2H-chromen-6-yl)-2-fluoro-but-2-enal (Compound 102, 107 mg, 0.29 mmol) were reacted to give the title compound as a yellow oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexane).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4c4e3378d0704ef681de7e340672da1a
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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