Sodium Hydroxide → HCID 22491011, compound

Participants

Reaction Steps

Following General Procedure G, ethyl (2E,4E,6E)-7-(2,2-dimethyl-4-phenyl-7-propoxy-2H-chromen-6-yl)-6-fluoro-3-methyl-octa-2,4,6-trienoate (Compound 115, 131 mg, 0.27 mmol) was hydrolyzed with NaOH to yield a yellow oil after purification by column chromatography (silica gel, 100% hexane to 5% to 50% ethyl acetate in hexanes). The resulting oil was recrystallized from acetonitrile to produce the title compound as a yellow solid.

Provenance & Evidence