8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-carbaldehyde → 1-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-propan-1-ol

HRID 2180536Notes

Reaction equation

HRID 2180536 reaction equation
[Cl:1][C:2]1[C:3]([O:19][CH:20]([CH3:22])[CH3:21])=[C:4]([CH:17]=[O:18])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:13])([CH3:12])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15].[CH2:23]([Mg]Br)[CH3:24]>>[Cl:1][C:2]1[C:3]([O:19][CH:20]([CH3:22])[CH3:21])=[C:4]([CH:17]([OH:18])[CH2:23][CH3:24])[CH:5]=[C:6]2[C:11]=1[O:10][C:9]([CH3:12])([CH3:13])[CH:8]=[C:7]2[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 224909788-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-carbaldehyde2×HCID 178418443HCID 178418443, compound

Product 1

HCID 224908381-(8-Chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-yl)-propan-1-ol

Procedure

As described in General Procedure P, 8-chloro-7-isopropoxy-4-isopropyl-2,2-dimethyl-2H-chromene-6-carbaldehyde, (Compound 135, 0.98 g, 3.05 mmol) was treated with ethylmagnesium bromide (3 M in ether, 1.6 mL, 4.9 mmol) to give rise to the title compound as a yellow foam.

Sources & evidence

ORD record
ord-0adac4e96cea40d8900c020e1700878f
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

Loading…