Triethyl 2-fluoro-2-phosphonoacetate → HCID 69732150, compound

HRID 2180542Notes

Reaction equation

HRID 2180542 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6](P(OCC)(OCC)=O)[F:7])=[O:5].[Cl:16][C:17]1[C:18]([O:36][CH2:37][CH3:38])=[C:19]([C:32](=O)[CH2:33][CH3:34])[CH:20]=[C:21]2[C:26]=1[O:25][C:24]([CH3:28])([CH3:27])[CH:23]=[C:22]2[CH:29]([CH3:31])[CH3:30]>>[Cl:16][C:17]1[C:18]([O:36][CH2:37][CH3:38])=[C:19](/[C:32](/[CH2:33][CH3:34])=[C:6](/[F:7])\[C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH:20]=[C:21]2[C:26]=1[O:25][C:24]([CH3:28])([CH3:27])[CH:23]=[C:22]2[CH:29]([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 2734865Triethyl 2-fluoro-2-phosphonoacetateHCID 22490971HCID 22490971, compound2×

Product 1

HCID 69732150HCID 69732150, compound

Procedure

Following General Procedure K, triethyl-2-fluoro-2-phosphonoacetate (0.14 mL, 0.67 mmol) and 1-(8-chloro-4-isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)-propan-1-one (Compound 141, 75 mg, 0.23 mmol) were reacted to give the title compound as a yellow oil after purification by flash chromatography (silica gel, 1:9 ethyl acetate/hexane).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-cd896020399b491aa55363a57dc35776
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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