Diisobutylaluminumhydride → HCID 22490788, compound

Participants

Reaction Steps

Following General Procedure L, ethyl 3-(8-chloro-4-isopropyl-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enoate (Compound 146, 110 mg, 0.28 mmol) and diisobutylaluminum hydride (1 M in hexanes, 1.1 mL, 1.1 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 to 1:4 ethyl acetate/hexane).

Provenance & Evidence