Diisobutylaluminumhydride → HCID 20779596, compound

Participants

Reaction Steps

Following General Procedure L, ethyl 3-(8-chloro-4-isopropyl-7-methoxy-2,2-dimethyl-4-chromen-6-yl)-2-fluoro-pent-2-enoate (Compound 147, 242 mg, 0.59 mmol 1) and diisobutylaluminum hydride (1M in hexanes, 2.4 mL, 2.4 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 to 1:4 ethyl acetate/hexane).

Provenance & Evidence