Diisobutylaluminumhydride → HCID 22490894, compound

Participants

Reaction Steps

Following General Procedure L, ethyl 3-(8-chloro-4-isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)-2-fluoro-but-2-enoate (Compound 148, 2.04 g, 5.66 mmol) and diisobutylaluminum hydride (1M in hexanes, 11.7 mL, 11.7 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 1:9 to 1:4 ethyl acetate/hexane).

Provenance & Evidence