HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 86597841, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Triethyl 2-fluoro-2-phosphonoacetate | HCID 2734865 | — |
| Reactant | 1-(4,4-Dimethyl-6-ethoxy-1-isopropyl-3,4-dihydronaphthalen-7-yl)ethanone | HCID 22491007 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86597841 | HCID 86597841 | — |
Reaction Steps
As described in General Procedure F-1, 1-(4,4-dimethyl-6-ethoxy-1-isopropyl-3,4-dihydronaphthalen-7-yl)ethanone (Compound A-24, 240 mg, 0.840 mmol) and triethyl 2-fluoro-2-phosphonoacetate (0.51 mL, 2.52 mmol) were reacted with lithium diisopropylamide (2.60 mmol) in THF (2 mL) to produce the title compound after purification by flash column chromatography (silica gel, 97:3 hexane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887896B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-616803406a7643909defaf73ba455192 |
| Source note | uspto-grants-2005_05 |