Lithium diisopropylamide → HCID 86597844, compound

Participants

Reaction Steps

As described in General Procedure F-1, 1-(7-bromo-4,4-dimethyl-6-propoxy-1-tert-butyl-3,4-dihydronaphthalen-yl)ethanone (Compound A-39, 34 mg, 0.11 mmol) and triethyl 2-fluoro-2-phosphonoacetate (0.17 mL, 0.86 mmol) were reacted with lithium diisopropylamide (0.86 mmol) in THF (2 mL) to produce the title compound as a yellow oil after purification by flash column chromatography (silica gel, 97:3 hexane:ethyl acetate).

Provenance & Evidence