Triethyl 2-fluoro-2-phosphonoacetate → HCID 86597855, compound

Participants

Reaction Steps

As described in General Procedure F-1, 1-(4-bromo-8-isopropyl-5,5-dimethyl-3-propoxy-5,6-dihydro-naphthalen-2-yl)-ethanone (Compound A-113, 202 mg, 0.53 mmol) and triethyl 2-fluoro-2-phosphonoacetate (516 mg, 2.12 mmol) were reacted with n-butyllithium (1.6 M in hexanes, 1.33 mL, 2.12 mmol) in THF to produce the title compound after purification by flash column chromatography (silica gel, 2% ethyl acetate in hexane).

Provenance & Evidence