Diisobutylaluminumhydride → HCID 22491029, compound

Participants

Reaction Steps

Following General Procedure G-1, (2E)-3-(4-bromo-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-4-methyl-pent-2-enoic acid ethyl ester (Compound A-127, 196 mg, 0.40 mmol) and diisobutylaluminum hydride (1 M in methylene chloride, 1.0 mL, 1.0 mmol) were reacted to give the title compound as a yellow syrup after purification by flash chromatography (silica gel, 10% ethyl acetate in hexanes).

Provenance & Evidence