Diisobutylaluminumhydride → HCID 22491003, compound

Participants

Reaction Steps

Following General Procedure G-1, ethyl (2E)-3-(4-bromo-3-isopropoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-but-2-enoate (Compound A-128, 282 mg, 0.60 mmol) and diisobutylaluminum hydride (1 M in methylene chloride, 2.4 mL, 2.4 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 10% ethyl acetate in hexanes).

Provenance & Evidence