Diisobutylaluminumhydride → HCID 22491084, compound

Participants

Reaction Steps

Following General Procedure G-1, ethyl (2E)-3-(4-bromo-8-tert-butyl-3-isopropoxy-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-but-2-enoate (Compound A-131, 115 mg, 0.24 mmol) and diisobutylaluminum hydride (1M in methylene chloride, 0.64 mL, 0.64 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 10% ethyl acetate in hexanes).

Provenance & Evidence