Diisobutylaluminumhydride → HCID 22490772, compound

Participants

Reaction Steps

As described in General Procedure G-1, (2E)-3-(4-bromo-8-sec-butyl-3-ethoxy-5,5-dimethyl-5,6-dihydronaphthalen-2-yl)-2-fluoro-pent-2-enoic acid ethyl ester (Compound A-132, 567 mg, 1.18 mmol) and diisobutylaluminum hydride (1M in methylene chloride, 2.84 mL, 2.84 mmol) were reacted to give the title compound as a colorless oil aft er purification by flash chromatography (silica gel, 10% to 15% ethyl acetate in hexanes).

Provenance & Evidence