Diisobutylaluminumhydride → HCID 22490906, compound

Participants

Reaction Steps

Following General Procedure G-1, ethyl (2E)-3-(4-chloro-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydronaphthalen-2-yl)-2-fluoro-but-2-enoate (Compound A-133, 0.27 g, 0.66 mmol) and diisobutylaluminum hydride (1M in methylene chloride, 2.64 mL, 2.64 mmol) were reacted to give the title compound as a colorless oil after purification by flash chromatography (silica gel, 10% to 15% ethyl acetate in hexanes).

Provenance & Evidence