Dichloromethane → HCID 22490823, compound

Participants

Reaction Steps

As described in General Procedure H-1, (2E)-3-(4-bromo-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-4-methyl-pent-2-en-1-ol (Compound A-138, 140 mg, 0.32 mmol), tetrapropylammonium perruthenate (10 mg, 0.028 mmol) and 4 methylmorpholine N-oxide (94 mg, 0.80 mmol) were reacted in acetonitrile and dichloromethane to give the title compound as a white solid after purification by flash column chromatography (silica gel, 5% ethyl acetate in hexane).

Provenance & Evidence