Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 86759718, compound

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Reaction Steps

Following General Procedure I-1, ethyl 4(diethoxyphosphoryl)-3-methyl-but-2E-enoate (92-mg, 0.35 mmol) and (2E)-3-(4-bromo-8-tert-butyl-3-ethoxy-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-but-2-enal (Compound A-152, 37 mg, 0.09 mmol) were reacted to give the title compound as a colorless oil after purification by column chromatography (silica gel, 2% ethyl acetate in hexane).

Provenance & Evidence