Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 86597867, compound

HRID 2180632Notes

Reaction equation

HRID 2180632 reaction equation
C(OP([CH2:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[Cl:18][C:19]1[C:28]2[C:27]([CH3:30])([CH3:29])[CH2:26][CH:25]=[C:24]([CH:31]([CH3:33])[CH3:32])[C:23]=2[CH:22]=[C:21](/[C:34](/[CH2:39][CH3:40])=[C:35](/[F:38])\[CH:36]=O)[C:20]=1[O:41][CH2:42][CH3:43]>>[Cl:18][C:19]1[C:28]2[C:27]([CH3:30])([CH3:29])[CH2:26][CH:25]=[C:24]([CH:31]([CH3:32])[CH3:33])[C:23]=2[CH:22]=[C:21](/[C:34](/[CH2:39][CH3:40])=[C:35](/[F:38])\[CH:36]=[CH:9]\[C:10](\[CH3:17])=[CH:11]\[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:20]=1[O:41][CH2:42][CH3:43]

Participants

3

Reactant 2

HCID 6000084Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoateHCID 86597860HCID 86597860, compound

Product 1

HCID 86597867HCID 86597867, compound

Procedure

Following General Procedure I-1, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (139 mg, 0.53 mmol) and (2E)-3-(4-chloro-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydronaphthalen-2-yl)-2-fluoro-pent-2-enal (Compound A-156, 32 mg, 0.09 mmol) were reacted to give the title compound as a colorless oil after purification by column chromatography (silica gel, 1% to 2% ethyl acetate in hexane).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d6f538b8f40a4e028ac0e49e3e779e4f
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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