Sodium Hydroxide → HCID 22490783, compound

HRID 2180636Notes

Reaction equation

HRID 2180636 reaction equation
[Br:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH:30]([CH3:32])[CH3:31])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([O:25]CC)=[O:24])[C:3]=1[O:33][CH2:34][CH3:35].[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:11]2[C:10]([CH3:12])([CH3:13])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH:30]([CH3:32])[CH3:31])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([OH:25])=[O:24])[C:3]=1[O:33][CH2:34][CH3:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86597861HCID 86597861, compound

Product 1

HCID 22490783HCID 22490783, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(4-bromo-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-6-fluoro-3,8-dimethyl-nona-2,4,6-trienoate (Compound A-160, 134 mg, 0.25 mmol) in ethanol was treated with a solution of 1 N aqueous NaOH to produce the title compound as a white solid after purification by recrystallization from acetonitrile.

Sources & evidence

ORD record
ord-e630d37e78314f8e973d9b6e5f6e2211
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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