Sodium Hydroxide → HCID 22490870, compound

HRID 2180638Notes

Reaction equation

HRID 2180638 reaction equation
[Br:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:18](/[CH3:31])=[C:19](/[F:30])\[CH:20]=[CH:21]\[C:22](\[CH3:29])=[CH:23]\[C:24]([O:26]CC)=[O:25])[C:3]=1[O:32][CH2:33][CH3:34].[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:11]2[C:10]([CH3:12])([CH3:13])[CH2:9][CH:8]=[C:7]([C:14]([CH3:17])([CH3:15])[CH3:16])[C:6]=2[CH:5]=[C:4](/[C:18](/[CH3:31])=[C:19](/[F:30])\[CH:20]=[CH:21]\[C:22](\[CH3:29])=[CH:23]\[C:24]([OH:26])=[O:25])[C:3]=1[O:32][CH2:33][CH3:34]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86759718HCID 86759718, compound

Product 1

HCID 22490870HCID 22490870, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(4 bromo-8-tert-butyl-3-ethoxy-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-6-fluoro-3-methyl-octa-2,4,6-trienoate (Compound A-163, 46 mg, 0.086 mmol) in ethanol was treated with a solution of 1 N NaOH to produce the title compound after purification by recrystallization from acetonitrile.

Sources & evidence

ORD record
ord-3b42d985736c459cbdeaab695f12a3f6
Source dataset
uspto-grants-2005_05
Patent number
US06887896B1

Reaction notes

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