Sodium Hydroxide → HCID 60003035, compound

HRID 2180641Notes

Reaction equation

[Cl:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH2:30][CH3:31])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([O:25]CC)=[O:24])[C:3]=1[O:32][CH2:33][CH3:34].[OH-].[Na+]>>[Cl:1][C:2]1[C:11]2[C:10]([CH3:12])([CH3:13])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:15])[CH3:16])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH2:30][CH3:31])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([OH:25])=[O:24])[C:3]=1[O:32][CH2:33][CH3:34]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86597867HCID 86597867, compound

Product 1

HCID 60003035HCID 60003035, compound

Procedure

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(4-chloro-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydronaphthalen-2-yl)-6-fluoro-3-methyl-nona-2,4,6-trienoate (Compound A-167, 30 mg, 0.06 mmol) was hydrolyzed with 1 N NaOH to produce the title compound as a solid after recrystallization from acetonitrile.

Sources & evidence

ORD record: ord-f82cd32b0f6b4b9f8522259b2ca7bfff
Source dataset: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06887896B1

Reaction notes

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