3-Pyridineacetic acid, hydrochloride (1:1) → N-[(3pyridyl)acetyl]-D,L-alanine iso-butyl ester

Participants

Reaction Steps

Following General Procedure F′ and using 3-pyridylacetic acid hydrochloride (Aldrich) and D,L-alanine isobutyl ester hydrochloride (from Example B′ above), the title compound was prepared as a solid having a melting point of 62°-64° C. The reaction was monitored by tlc on silica gel (Rf=0.48 10% methanol/dichloromethane) and purification was by silica gel chromatography.

Provenance & Evidence