3-Thiophenacetic acid → 2-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

HRID 2180721Notes

Reaction equation

HRID 2180721 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 234043-Thiophenacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 542657592-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure I′ above and using 3-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tic on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-d32265673aea40a4a5f4958f6f498050
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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