Benzeneacetic acid, 4-bromo- → 2-[(4-Bromophenyl)acetamido]butyric acid isobutyl ester

HRID 2180726Notes

Reaction equation

HRID 2180726 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 74654Benzeneacetic acid, 4-bromo-HCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476402-[(4-Bromophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I′ above and using 4-bromophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-45dd60b6b08248a59958451a28c9cea3
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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