3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

HRID 2180741Notes

Reaction equation

HRID 2180741 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 22894975N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I′ above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-d13b833876564e8ba19a26503bfd5428
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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