Cyclohexaneacetic acid → N-(cyclohexyIacetyl)-L-alanine iso-butyl ester

Participants

Reaction Steps

Following General Procedure B′ above, and using cyclohexylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example B′ above), 5 the title compound was prepared as a solid having a melting point of 92° C.-93° C. The reaction was monitored by tlc on silica gel (Rf=0.39 in 1:3 EtOAc:hexane) and purification was by extraction with EtO followed by washes with aqueous K2CO3 and aqueous HCl.

Provenance & Evidence