L-Alanine ethyl ester → N-[(2-phenyl)-2-fluoroacetyl]alanine Ethyl Ester

Participants

Reaction Steps

Following General Procedure F′ above, and using α-fluorophenyl acetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification was by chromatography on silica gel using 1:2 ethyl acetate/hexanes as the eluent.

Provenance & Evidence