HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 10201278, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | HCID 86585126 | HCID 86585126 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 10201278 | HCID 10201278 | — |
Reaction Steps
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2) and methyl (S)-2-amino-3-(3-pyridyl)propionate hydrochloride (Synthetech), the title compound was prepared as a solid (mp 101-103° C.). The reaction was monitored by tlc (Rf=0.48 in 10% MeOH/DCM) and the product was purified by silica gel column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06888022B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-23f83f9a29b740fdaddb31175d26a4be |
| Source note | uspto-grants-2005_05 |