HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl acetamido[(pyridin-3-yl)methyl]propanedioate | HCID 13817914 | — |
| Product | H-Ala(3-pyridyl)-OMe.2HCl | HCID 46862166 | 100% |
Reaction Steps
Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MEOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacua to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06888022B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-2353bf30d22a4ea28061ddd3e989e688 |
| Source note | uspto-grants-2005_05 |