HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-leucine tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | tert-butyl (2S)-2-amino-4-methylpentanoate hydrochloride | HCID 12451443 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-leucine tert-Butyl Ester | HCID 22894891 | — |
Reaction Steps
Following General Procedure B and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-leucine tert-butyl ester hydrochloride (Bachem), the title compound was prepared as a solid (mp=128° C.). The reaction was monitored by tlc (Rf=0.85 in 5% MeOH/methylene chloride) and the product was purified by flash column chromatography using 5% MeOH/methylene chloride as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06888022B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b4f7d959bbdc47a2ad961b3c4bf21273 |
| Source note | uspto-grants-2005_05 |