Methyl L-threoninate hydrochloride → N-[N-(Phenylacetyl)-L-alaninyl]-L-threonine Methyl Ester

HRID 2180791Notes

Reaction equation

HRID 2180791 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][C:19](=[O:25])[C@H:20]([C@@H:22]([CH3:24])[OH:23])[NH2:21]>>[CH3:17][O:18][C:19](=[O:25])[C@H:20]([C@@H:22]([CH3:24])[OH:23])[NH:21][C:13](=[O:15])[C@H:11]([CH3:12])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 2734893Methyl L-threoninate hydrochlorideHCID 7004640N-(Phenylacetyl)-L-alanine

Product 1

HCID 9901704N-[N-(Phenylacetyl)-L-alaninyl]-L-threonine Methyl Ester

Procedure

Following General Procedure U and using N-(phenylacetyl)-L-alanine (from Example B1 above) and L-threonine methyl ester hydrochloride (Bachem), the title compound was prepared as a solid.

Sources & evidence

ORD record
ord-dc21ac8a73d24087867a1d8691c42209
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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