HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isovaleric Acid → HCID 22895037, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isovaleric Acid | HCID 10430 | — |
| Reactant | L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- | HCID 77857 | — |
| Reactant | HCID 69622900 | HCID 69622900 | — |
| Reactant | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | HCID 22895037 | HCID 22895037 | — |
Reaction Steps
Following General Procedure C and using isovaleric acid (Aldrich) and N-(L-phenylalaninyl)-L-alanine iso-butyl ester hydrochloride (prepared from N-BOC-L-phenylalanine (Sigma) and L-alanine iso-butyl ester hydrochloride (prepared as described in Example 83A above) using General Procedure C, followed by removal of the BOC-group using General Procedure P), the title compound was prepared as a solid (mp=135-138° C.). The reaction was monitored by tlc (Rf=0.3 in 3% MeOH/CHCl3) and the product was purified by silica gel chromatography using 3% MeOH/CHCl3 as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06888022B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-6db2fb0da0694910a4fd2762d4e246a4 |
| Source note | uspto-grants-2005_05 |