HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 66930179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66921046 | HCID 66921046 | — |
| Reactant | HCID 131728709 | HCID 131728709 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66930179 | HCID 66930179 | — |
Reaction Steps
This compound was prepared from N—[(S)-1-((3S,3aS,6R,6aS)-6-chloro-3-hydroxy-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid tert-butyl ester by a series of deprotection (acetyl chloride, MeOH) and HATU-mediated coupling steps with Boc-leucine initially, and finally 3-fluoro-4-[2-(4-methylpiperazin-1-yl)-thiazol-4-yl]benzoic acid HCl salt prepared as described in Example 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198283B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-8bd700069e0d45c3b5de57795a5430a3 |
| Source note | uspto-grants-2012_06 |