Morpholine → HCID 22894830, compound

Participants

Reaction Steps

Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (from Example D 1 above) and 4-(L-isoleucinyl)morpholine (prepared from N-BOC-L-isoleucine (Aldrich) and morpholine (Aldrich) using General Procedure M, followed by removal of the BOC-group using General Procedure P), the title compound was prepared as a solid (mp=156-160° C.). The reaction was monitored by tlc (Rf=0.45 in 9:1 CHCl3/MeOH) and the product was purified by silica gel chromatography using 98:2 CHCl3/MeOH as the eluent.

Provenance & Evidence