Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2180839Generated: October 29, 2026

(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 22894859, compound

https://huagongshe.com/reaction/2180839

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 12135350—
Reactantmethyl amino(3-fluorophenyl)acetate hydrochlorideHCID 22492173—
SolventChloroform methanolHCID 21584188—
ProductHCID 22894859HCID 22894859—

Reaction Steps

Following General Procedure C and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 2-amino-2-(3-fluorophenyl)acetate hydrochloride (from EXAMPLE D12 above), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.2 in 95:5 CHCl3/MeOH) and the product was purified by silica gel chromatography using 95:5 CHCl3/MeOH as the eluent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06888022B2
Source datasetuspto-grants-2005_05
ORD IDord-fedbafa92b0f4792a332bbe8d134d469
Source noteuspto-grants-2005_05