Leucine methyl ester hydrochloride → N-[N-(Phenylacetyl)-L-alaninyl]-L-leucine Methyl Ester

HRID 2180852Notes

Reaction equation

HRID 2180852 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH2:21]>>[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH:21][C:13](=[O:15])[C@H:11]([CH3:12])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 2723695Leucine methyl ester hydrochlorideHCID 7004640N-(Phenylacetyl)-L-alanine

Product 1

HCID 9923756N-[N-(Phenylacetyl)-L-alaninyl]-L-leucine Methyl Ester

Procedure

Following General Procedure A and using N-(phenylacetyl)-L-alanine (from Example B1 above) and L-leucine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid (mp=102.5-105° C.). The reaction was monitored by tlc (Rf=0.25 in 50% EtOAc/hexanes).

Sources & evidence

ORD record
ord-a94ff7debaf043fcb3233f333255f059
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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